ABSTRACT
Objective To investigate the diagnostic feasibility of acute tubular necrosis(ATN) in renal allograft using time intensity curves by intravenous contrast ultrasound.Methods The canine models of acute tubular necrosis in renal allograft were established,and examined subsequently with intravenous contrast ultrasound using auto control,and also the parameters of time intensity curves were analyzed,tracking the renal biopsies simultaniously.Results After ATN occured, the curve peak was ante displaced.And parameters of TIC (except peak intensity,PI),area under the curve(AUC),half time of descent(HT),mean transit time(MTT),the ratio of AUC were decreased dramatically.Conclusions Contrast ultrasound combined with TIC quantitative analysis could reflect the variation of blood perfusion objectively,and it is a potential new method for diagnosis of ATN in renal allograft.